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Briefing
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- World’s Smallest Tape Recorder — Researchers at Columbia University Medical Center modified human gut microbe Escherichia coli enabling it to record environment and time-stamp events
- First for CRISPR — Takes advantage of CRISPR-Cas which naturally keeps record of DNA of viruses it survived, first time CRISPR is used to record cellular activity and timing of events
- How It Was Made — Bioengineered plasmid DNA in bacterial cell to give it ability to create copies of itself in response to external signal, which works alongside another recording plasmid that records and marks time, creating microsystem that can record signal sequences and time depending on cell’s environment
- Potential Applications — Include biosensors for disease diagnosis and environmental monitoring
- Next Steps — Enable recorder to respond to disease biomarkers in digestive system that may fluctuate or change
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Accelerator
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Sector
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Healthcare/Health Sciences
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Organization
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Columbia University Medical Center
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Source
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Original Publication Date
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November 23, 2017
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