Briefing

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Broad Institute researchers developed improved CRISPR gene editing system called prime editing that can correct 89% of genetic mutations

October 29, 2019

Briefing:
  • Prime Editing – Genetic researchers David Liu and Andrew Anzalone from Broad Institute created prime editing, a modified, more flexible and safer gene editing system than CRISPR
  • What It Does – Can make additions, deletions and swap any single letter in DNA for healthy one
  • How It Works – Combines molecule that functions like scalpel and reverse transcriptase, which converts RNA into DNA and installs corrected copy of DNA, not just editing out mutations or errors like in CRISPR
  • Genetic Diseases – Does not rely on cells dividing to correct DNA, making it applicable for many genetic or inherited diseases caused by mutations in cells in nervous system
  • Safer Method – Technique does not cut both strands of DNA double helix, minimizing chances of making unintended changes that could be dangerous
  • 175 Edits – Conducted 175 gene edits, including three mutations that cause sickle cell anemia, cystic fibrosis and Tay-Sachs disease, as reported in paper published in Nature

Image Source: Pixabay

DNA

Image Source: Pixabay

Sector: Healthcare/Health Sciences
Function: Research and Development
Organization: Broad Institute
Source: 

Original Publication Date: October 21, 2019

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