Broad Institute scientists adapted CRISPR to develop new tool that enables diagnosis of Zika virus, cancer, and antibiotic resistance genes

Briefing

Broad Institute scientists adapted CRISPR to develop new tool that enables diagnosis of Zika virus, cancer, and antibiotic resistance genes

April 27, 2017

Briefing

  • CRISPR Diagnostics Tool – Scientists from Broad Institute of MIT and Harvard developed new tool, SHERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing), which harnesses CRISPR (clustered regularly interspaced short palindromic repeats) protein Cas13a to detect presence of specific molecules in blood or saliva sample, enabling wide range diagnostic development
  • How It Works – Makes RNA copies of DNA and uses CRISPR to target specific genetic sequences, showing fluorescence when it finds presence of target
  • Multiple Applications – Can diagnose Zika virus, detect cancer mutations, and track antibiotics resistance genes
  • Outbreak Diagnostics Test – Used as paper test for Zika virus and other epidemics that can be easily deployed in rural areas, and costs just 61 cents

Accelerator

Sector

Healthcare/Health Sciences

Organization

Broad Institute

Source

Original Publication Date

April 13, 2017

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