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Briefing
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- Prime Editing – Genetic researchers David Liu and Andrew Anzalone from Broad Institute created prime editing, a modified, more flexible and safer gene editing system than CRISPR
- What It Does – Can make additions, deletions and swap any single letter in DNA for healthy one
- How It Works – Combines molecule that functions like scalpel and reverse transcriptase, which converts RNA into DNA and installs corrected copy of DNA, not just editing out mutations or errors like in CRISPR
- Genetic Diseases – Does not rely on cells dividing to correct DNA, making it applicable for many genetic or inherited diseases caused by mutations in cells in nervous system
- Safer Method – Technique does not cut both strands of DNA double helix, minimizing chances of making unintended changes that could be dangerous
- 175 Edits – Conducted 175 gene edits, including three mutations that cause sickle cell anemia, cystic fibrosis and Tay-Sachs disease, as reported in paper published in Nature
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Accelerator
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Sector
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Healthcare/Health Sciences
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Function
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Research and Development
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Organization
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Broad Institute
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Source
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Original Publication Date
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October 21, 2019
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