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Briefing
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- Suppressing HIV-1 DNA – Team of scientists first to suppress HIV DNA from living animal genomes using gene editing technology CRISPR/Cas9, performing procedure in three different animal models, including "humanized" model of mice transplanted with human immune cells
- Animal Subjects – Observed how CRISPR/Cas9 blocks viral replication and systemic infection in mice with human immune cells affected by HIV-1 and with EcoHIV, mouse equivalent of HIV-1
- Bioluminescence Imaging System – Used novel technology that identifies location of HIV-1 infected cells, allowing detection of replication in real-time and ability to virtually see HIV-1 reservoirs in passively infected cells and tissues
- Next Steps – Replicate study using primates as subject, with ultimate goal of doing clinical trials on humans affected by said virus
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Accelerator
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Sector
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Healthcare/Health Sciences
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Organization
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Temple University, University of Pittsburgh
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Source
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Original Publication Date
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May 1, 2017
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